A review on in-vivo animal models for articular cartilage regeneration: osteoarthritis defects

Reconstruction of articular cartilage degenerative diseases such as osteoarthritis is one of the most important challenges in musculoskeletal medicine. So far, a lot of research has been done on the repair of damaged articular cartilage in vivo. The study of in vivo animal models is essential to evaluate cartilage tissue engineering techniques. In this review, we study the articular cartilage structure and osteoarthritis disease features. Also, animal species that have been used in various studies as a model of articular cartilage damage and the advantages and disadvantages of any species models were studied.