生物
表位
单克隆抗体
抗原
T细胞
受体
T细胞受体
分子生物学
糖蛋白
细胞生物学
T淋巴细胞
抗体
免疫学
生物化学
免疫系统
作者
Stefan Meuer,Rebecca E. Hussey,Marina Fabbi,David A. Fox,Oreste Acuto,Kathleen A. Fitzgerald,James C. Hodgdon,Jeffrey P. Protentis,Stuart F. Schlossman,Ellis L. Reinherz
出处
期刊:Cell
[Elsevier]
日期:1984-04-01
卷期号:36 (4): 897-906
被引量:1115
标识
DOI:10.1016/0092-8674(84)90039-4
摘要
A series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T11(1), the SRBC binding site expressed on all T lymphocytes and thymocytes; T11(2), an epitope unrelated to the SRBC binding site but with a similar distribution; and T11(3), a neo-epitope expressed only upon T-cell activation. Simultaneous triggering of T11(2) and T11(3) epitopes by monoclonal antibodies induces T lymphocytes to proliferate and mediate their functional programs in the absence of antigen and/or antigen-presenting cells. This antigen-independent mode of triggering is distinct from that involving the T3-Ti antigen receptor complex and represents an alternate pathway of T-cell activation. Given that T11 is the earliest T-lineage surface glycoprotein to appear in thymic ontogeny and is thus expressed before T3-Ti, the former may be involved in clonal expansion and/or differentiation during early development.
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