药品
医学
药物输送
联合疗法
纳米技术
毒品携带者
抗药性
靶向给药
纳米医学
癌症治疗
癌症
药理学
纳米颗粒
材料科学
内科学
生物
微生物学
作者
Pengxiao Cao,Younsoo Bae
出处
期刊:Future Oncology
[Future Medicine]
日期:2012-11-01
卷期号:8 (11): 1471-1480
被引量:27
摘要
This review describes the scientific background, current achievement and future perspective of combination therapy using polymer nanoparticle drug carriers in cancer treatment. Nanotechnology-based drug delivery is expected to dramatically change combination cancer therapy by controlling accumulation and distribution patterns of multiple drugs selectively in disease sites. Rationally designed polymer materials can produce functional nanoparticulate drug carriers that can be used in various biomedical applications. In comparison with conventional drug combination approaches, using polymer nanoparticle drug carriers appears to suppress tumor growth more efficiently, potentially overcoming multidrug resistance in many cancers. It also provides versatile combination options for a variety of therapeutic agents, molecular targeting agents and nucleotide drugs.
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