表观基因组
生物
重编程
染色质
全能的
表观遗传学
组蛋白
染色质重塑
合子
细胞生物学
母子转换
诱导多能干细胞
后生
遗传学
体细胞
DNA甲基化
生殖系
胚胎干细胞
干细胞
胚胎
表观遗传学
进化生物学
胚胎发生
基因
基因表达
标识
DOI:10.1016/j.tcb.2017.10.008
摘要
Drastic epigenetic reprogramming takes place during preimplantation development, leading to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in remodeling of the epigenomes can cause severe developmental defects, including embryonic lethality. However, how chromatin modifications and chromatin organization are reprogrammed upon fertilization in mammals has long remained elusive. Here, we review recent progress in understanding how the epigenome is dynamically regulated during early mammalian development. The latest studies, including many from genome-wide perspectives, have revealed unusual principles of reprogramming for histone modifications, chromatin accessibility, and 3D chromatin architecture. These advances have shed light on the regulatory network controlling the earliest development and maternal-zygotic transition.
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