特发性肺纤维化
肺
病理
肌成纤维细胞
间质细胞
间充质干细胞
肺纤维化
人口
生物
慢性阻塞性肺病
纤维化
医学
细胞
电池类型
内科学
环境卫生
遗传学
作者
Taylor Adams,Jonas C. Schupp,Sergio Poli,Ehab Ayaub,Nir Neumark,Farida Ahangari,Sarah G. Chu,Benjamin A. Raby,Giuseppe DeIuliis,Michael Januszyk,Qiaonan Duan,Heather A. Arnett,Asim Siddiqui,George R. Washko,Robert J. Homer,Xiting Yan,Iván O. Rosas,Naftali Kaminski
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2020-07-10
卷期号:6 (28)
被引量:733
标识
DOI:10.1126/sciadv.aba1983
摘要
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs. Among epithelial cells enriched in IPF, we identify a previously unidentified population of aberrant basaloid cells that coexpress basal epithelial, mesenchymal, senescence, and developmental markers and are located at the edge of myofibroblast foci in the IPF lung. Among vascular endothelial cells, we identify an ectopically expanded cell population transcriptomically identical to bronchial restricted vascular endothelial cells in IPF. We confirm the presence of both populations by immunohistochemistry and independent datasets. Among stromal cells, we identify IPF myofibroblasts and invasive fibroblasts with partially overlapping cells in control and COPD lungs. Last, we confirm previous findings of profibrotic macrophage populations in the IPF lung. Our comprehensive catalog reveals the complexity and diversity of aberrant cellular populations in IPF.
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