Longitudinal study on the relationship between hyperlipidemia and hyperuricemia in medical workers

Objective To investigate the relationship between hyperlipidemia and hyperuricemia. Methods From February 1, 2012 to May 31, 2017, a physical examination queue for serving and retired employees in Xiangya Hospital was established. As the survey's baseline, height, weight, waist circumference, blood lipids, blood pressure, blood glucose, creatinine, and serum uric acid were collected. The normal group was the control group, and the dyslipidemia group was the exposure group. The occurrence of hyperuricemia was investigated during follow-up. A multivariate Cox proportional hazards regression model was used to analyze hyperlipidemia. Four different clinical types (hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, and low high-density lipoprotein hyperlipidemia) and hyperuricemia had an incidence of hazard ratio (HR) and confidence interval (95%CI). Results A total of 1 553 people entered the follow-up cohort. A total of 5 297 patients were followed up for an average of 3.4 years. Three hundred and ninety-four cases of hyperuricemia were collected. The density of hyperuricemia was 744/10 000 years. The hyperuricemia group was followed up for 2 509 years, with hyperuricemia occurring in 142 cases, and hyperuricemia in the hyperlipidemia group of 566/million years. The hypercholesterolemia, high triglyceride, mixed hyperlipidemia, and low-density lipoprotein groups were followed up for 1 431, 403, 580, 92 years, respectively, and high uric acid occurred respectively. In 105, 64, 72 and 11 cases, the incidence of disease was 734/million years, 1 588/million years, 1 241/million years, 1 196/million years;the difference was statistically significant (P< 0.01). Hyperlipidemia and its four clinical types, hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, and hypodic lipoproteinemia, were associated with hyperuricemia. HR (95%CI) was 1.971 (1.604-2.421), 1.441 (1.120-1.855), 3.103 (2.309-4.169), 2.434 (1.833-3.233), 2.336, respectively. (1.265-4.316), P< 0.01; after adjusting the influence of age, sex, body mass index, hypertension, hyperglycemia, and hyper creatinine, HR (95%CI) was 1.885 (1.533-2.317), 1.450 (1.127-1.866), 2.881 (2.141-3.876), 2.118 (1.588-2.825), 2.451 (1.326-4.528) P< 0.01. Conclusions Hyperlipidemia and its four different clinical types (hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, and low-density lipoproteinemia) are all associated with the onset of hyperuricemia. Key words: Hyperlipidemia; Hyperuricemia; Longitudinal study