聚酮
真菌
戒指(化学)
立体化学
青霉属
碳骨架
拉伤
生物
化学
植物
生物化学
生物合成
有机化学
基因
解剖
作者
Yi Zang,Yihua Gong,Jiaojiao Gong,Junjun Liu,Chunmei Chen,Lianghu Gu,Yuan Zhou,Jianping Wang,Hucheng Zhu,Yonghui Zhang
标识
DOI:10.1021/acs.joc.0c00147
摘要
Four unusual polyketides possessing three unambiguous chemical architectures were discovered from the fermentation of Penicillium canescens assisted by the one strain-many compounds (OSMAC) strategy and MS2-based molecular networking. Penicanone (1) is the first naturally occurring polyketide characterized by a 6/6/8 tricyclic carbon skeleton incorporating an unusual bicyclo[5.3.1]hendecane core. Penicanesones A–C (2–4) are aromatic polyketide dimers simultaneously featuring inconsistent 6/5/5/6 and 6/6/5/6 heterotetracyclic ring cores. Their plausible biosynthetic pathways and screening of biological activity were described here.
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