The competent combination of the state regional policy of the US federal center with market relations allowed the country to achieve advanced results in innovative activities. At the same time, the regional aspect of the spatial organization of innovations within the regional innovation systems of the United States, which has become the subject of this study, is largely characterized by the influence of specific organizational and territorial forms, within which certain instruments of state regional innovation policy are implemented. The paper identifies the main “center-peripheral” tendencies of innovation activity (at the level of statistical regions of the United States), which have developed under the influence of the US state regional policy on the development of these systems. Revealed, on the whole unambiguous in direction, but having regional differences, the relationship between the level of innovative development of territories and the activity of state regulation of innovative activities.