亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration

组蛋白甲基转移酶 组蛋白 生物 表观遗传学 组蛋白甲基化 染色质 组蛋白密码 DNA修复 细胞生物学 组蛋白H2A 甲基转移酶 染色质重塑 甲基化 DNA甲基化 生物化学 核小体 DNA 基因表达 基因
作者
Madhusoodanan Urulangodi,Abhishek Mohanty
出处
期刊:Journal of Cell Communication and Signaling [Springer Science+Business Media]
卷期号:14 (1): 31-45 被引量:20
标识
DOI:10.1007/s12079-019-00538-2
摘要

Protein post-translational modifications (PTMs) have emerged to be combinatorial, essential mechanisms used by eukaryotic cells to regulate local chromatin structure, diversify and extend their protein functions and dynamically coordinate complex intracellular signalling processes. Most common types of PTMs include enzymatic addition of small chemical groups resulting in phosphorylation, glycosylation, poly(ADP-ribosyl)ation, nitrosylation, methylation, acetylation or covalent attachment of complete proteins such as ubiquitin and SUMO. Protein arginine methyltransferases (PRMTs) and protein lysine methyltransferases (PKMTs) enzymes catalyse the methylation of arginine and lysine residues in target proteins, respectively. Rapid progress in quantitative proteomic analysis and functional assays have not only documented the methylation of histone proteins post-translationally but also identified their occurrence in non-histone proteins which dynamically regulate a plethora of cellular functions including DNA damage response and repair. Emerging advances have now revealed the role of both histone and non-histone methylations in the regulating the DNA damage response (DDR) proteins, thereby modulating the DNA repair pathways both in proliferating and post-mitotic neuronal cells. Defects in many cellular DNA repair processes have been found primarily manifested in neuronal tissues. Moreover, fine tuning of the dynamicity of methylation of non-histone proteins as well as the perturbations in this dynamic methylation processes have recently been implicated in neuronal genomic stability maintenance. Considering the impact of methylation on chromatin associated pathways, in this review we attempt to link the evidences in non-histone protein methylation and DDR with neurodegenerative research.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
三三发布了新的文献求助10
2秒前
方远锋发布了新的文献求助10
3秒前
3秒前
宋宋不迷糊完成签到 ,获得积分10
4秒前
5秒前
打打应助计蒙采纳,获得10
6秒前
笋笋完成签到,获得积分10
9秒前
damonvincent发布了新的文献求助30
10秒前
12秒前
Ava应助三三采纳,获得10
15秒前
思源应助大方的青柏采纳,获得10
19秒前
20秒前
冷静橘子完成签到,获得积分10
20秒前
小贝完成签到,获得积分10
22秒前
23秒前
28秒前
28秒前
科目三应助计蒙采纳,获得10
30秒前
笨笨的怜雪完成签到 ,获得积分10
33秒前
小贝发布了新的文献求助30
36秒前
36秒前
充电宝应助小萝卜1234采纳,获得10
42秒前
娃娃跑乡发布了新的文献求助10
42秒前
三三发布了新的文献求助10
42秒前
淡定小馒头应助热情的竺采纳,获得10
43秒前
48秒前
YifanWang应助科研通管家采纳,获得10
49秒前
OsamaKareem应助科研通管家采纳,获得200
49秒前
汉堡包应助科研通管家采纳,获得10
49秒前
56秒前
58秒前
科研通AI6.4应助计蒙采纳,获得10
58秒前
1分钟前
叶子发布了新的文献求助10
1分钟前
鹿小新完成签到 ,获得积分0
1分钟前
1分钟前
1分钟前
小贝发布了新的文献求助10
1分钟前
1分钟前
1分钟前
高分求助中
Malcolm Fraser : a biography 680
Signals, Systems, and Signal Processing 610
天津市智库成果选编 600
Climate change and sports: Statistics report on climate change and sports 500
Forced degradation and stability indicating LC method for Letrozole: A stress testing guide 500
Organic Reactions Volume 118 400
A Foreign Missionary on the Long March: The Unpublished Memoirs of Arnolis Hayman of the China Inland Mission 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6457256
求助须知:如何正确求助?哪些是违规求助? 8267246
关于积分的说明 17620471
捐赠科研通 5524679
什么是DOI,文献DOI怎么找? 2905381
邀请新用户注册赠送积分活动 1882080
关于科研通互助平台的介绍 1725998