A New Study to Improve the Interfacial Compatibility Between Collagen and Textile Blood Vessels

ABSTRACT Collagen coatings are widely used in the field of artificial blood vessels for improving the anti‐bleeding and biocompatibility of vascular scaffolds, which has become a hotspot of international research. However, there has always been the challenge of poor interfacial compatibility between polyester, the artificial vascular material, and collagen, the natural biomaterial, with insufficient adhesion between the two, which can easily result in detachment and fail to meet the requirements for clinical use. To address the above problems, this study proposes to use the balloon dilatation technique, increasing the adhesion between the collagen and the vessel surface by pressurized treatment. The experimental results showed that textile blood vessels treated in a 37°C oven for 45 min were able to maintain the integrity and wettability of the collagen coating at a pressure of 5 atm. The pressurized treatment significantly increased the adhesion between the collagen and the textile vessel surface and effectively reduced the thickness of the collagen membrane, resulting in a significant increase in its densification. In conclusion, balloon dilatation and compression treatment is an effective technique to enhance the interfacial compatibility between collagen coatings and textile vessels and to reduce the risk of thrombosis, which has a broad application prospect.