Rosai-Dorfman disease of the colon

Rosai-Dorfman disease (RDD), formerly referred to as "sinus histiocytosis with massive lymphadenopathy," was first described by Rosai and Dorfman in 1969. 1 Rosai J. Dorfman R.F. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969; 87: 63-70 PubMed Google Scholar Initially believed to be a disease limited to the lymph nodes, RDD is now recognized as involving a variety of organs. Although GI involvement has been reported, it remains rare. To our knowledge, there have been no cases of RDD reported in the gastroenterology literature and no cases evaluated with EUS.