白藜芦醇
体内
SKBR3型
药理学
固体脂质纳米粒
多重耐药
细胞凋亡
乳腺癌
联合疗法
体外
癌症
医学
化学
癌症研究
药品
生物化学
生物
内科学
抗生素
生物技术
人体乳房
作者
Wenrui Wang,Mengyang Zhou,Xu Yang,Wei Peng,Shiwen Zhang,Rongjie Li,Han Zhang,Hui Zhang,Shumin Cheng,Youjing Wang,Xinyu Wei,Chengxu Yue,Qingling Yang,Changjie Chen
标识
DOI:10.3389/fbioe.2021.762489
摘要
Multidrug resistance (MDR) is a serious problem during cancer therapy. The purpose of the present study was to formulate D-α-Tocopheryl polyethylene glycol 1000 succinate-resveratrol-solid lipid nanoparticles (TPGS-Res-SLNs) to improve its therapeutic efficacy against breast cancer. In this study, the solvent injection method was used to prepare the TPGS-Res-SLNs. It was found that the TPGS-Res-SLNs exhibited zeta potential and drug-loading of −25.6 ± 1.3 mV and 32.4 ± 2.6%, respectively. Therefore, it was evident that the TPGS-Res-SLNs can increase cellular uptake of chemotherapeutic drugs, induce mitochondrial dysfunction, and augment tumor treatment efficiency by inducing apoptosis. Moreover, it was found that SKBR3/PR cells treated with TPGS-Res-SLNs exhibited significant inhibition of cell migration and invasion, as compared with free resveratrol. In addition, results from in vivo SKBR3/PR xenograft tumor models revealed that TPGS-Res-SLNs has better efficacy in promoting apoptosis of tumor cells owing to high therapeutic outcomes on tumors when compared with the efficacy of free resveratrol. In conclusion, the findings of the present study indicate significant potential for use of TPGS-Res-SLNs as an efficient drug delivery vehicle to overcome drug resistance in breast cancer therapy.
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