Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants

痴呆 前瞻性队列研究 体质指数 医学 队列 队列研究 内科学 生理学 疾病
作者
Yue‐Ting Deng,Yuzhu Li,Shu‐Yi Huang,Ya‐Nan Ou,Wei Zhang,Shi-Dong Chen,Ya-Ru Zhang,Yang Liu,Qiang Dong,Jianfeng Feng,John Suckling,A. David Smith,Wei Cheng,Jin‐Tai Yu
出处
期刊:Molecular Psychiatry [Springer Nature]
卷期号:27 (8): 3385-3395 被引量:23
标识
DOI:10.1038/s41380-022-01604-9
摘要

Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size (p < 0.001). A strong U-shaped association was observed between adult BMI and dementia. More fat and less fat-free mass distribution on arms were associated with a higher risk of dementia. Interestingly, similar U-shaped associations were found between BMI and four metabolites (i.e., 3-hydroxybutrate, acetone, citrate and polyunsaturated fatty acids), four inflammatory cells (i.e., neutrophil, lymphocyte, monocyte and leukocyte) and abnormalities in brain structure that were also related to dementia. The findings that adiposity is associated with metabolites, inflammatory cells and abnormalities in brain structure that were related to dementia risk might provide clues to underlying biological mechanisms. Interventions to prevent dementia should begin early in life and include not only BMI control but fat distribution and body composition.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
明理糖豆完成签到 ,获得积分10
刚刚
chrysan完成签到,获得积分10
1秒前
雨后完成签到 ,获得积分10
3秒前
涂涂完成签到 ,获得积分10
6秒前
HuFan1201完成签到 ,获得积分10
9秒前
chen完成签到 ,获得积分10
10秒前
zyj完成签到 ,获得积分10
11秒前
WYX完成签到 ,获得积分10
12秒前
蔺天宇完成签到,获得积分10
13秒前
15秒前
Lost7完成签到 ,获得积分10
16秒前
胖胖完成签到 ,获得积分0
17秒前
CuteG完成签到 ,获得积分10
17秒前
18秒前
张立佳完成签到 ,获得积分10
23秒前
杀猪刀发布了新的文献求助10
24秒前
28秒前
kylin完成签到,获得积分10
29秒前
李振博完成签到 ,获得积分10
29秒前
兴奋渊思完成签到 ,获得积分10
30秒前
33秒前
33秒前
tfq200完成签到,获得积分10
35秒前
36秒前
Solar energy发布了新的文献求助10
38秒前
Snowy周完成签到,获得积分10
42秒前
labordoc完成签到,获得积分10
44秒前
薛微有点甜完成签到 ,获得积分10
45秒前
56秒前
Steven发布了新的文献求助30
57秒前
Jeremy637完成签到 ,获得积分10
59秒前
qqy发布了新的文献求助10
1分钟前
ZH完成签到 ,获得积分10
1分钟前
831143完成签到 ,获得积分0
1分钟前
无情灯泡发布了新的文献求助30
1分钟前
WSYang完成签到,获得积分10
1分钟前
livra1058完成签到,获得积分10
1分钟前
濠哥妈咪完成签到,获得积分10
1分钟前
Kelly完成签到 ,获得积分10
1分钟前
小二郎应助科研通管家采纳,获得10
1分钟前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Continuum Thermodynamics and Material Modelling 2000
Encyclopedia of Geology (2nd Edition) 2000
105th Edition CRC Handbook of Chemistry and Physics 1600
Maneuvering of a Damaged Navy Combatant 650
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
Mixing the elements of mass customisation 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3779313
求助须知:如何正确求助?哪些是违规求助? 3324815
关于积分的说明 10220137
捐赠科研通 3039971
什么是DOI,文献DOI怎么找? 1668528
邀请新用户注册赠送积分活动 798717
科研通“疑难数据库(出版商)”最低求助积分说明 758503