酸浆
茄科
立体化学
人体乳房
IC50型
含烷醇
化学
癌细胞系
传统医学
生物
植物
癌细胞
体外
生物化学
癌症
基因
医学
遗传学
替代医学
病理
索马里风
作者
Qian-Ran Li,Huijun Liang,Bailin Li,Zhuo-Yi Ao,Yu-Wen Fan,Wei-Jie Zhang,Xin Lian,Jia-Yan Chen,Juanjuan Hu,Jie Yuan,Jiunn‐Tzong Wu
标识
DOI:10.1080/10286020.2022.2095263
摘要
Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3–14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC50 value of 3.51 µM and compounds 2, 6 and 14 showed weak cytotoxic effect.
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