咖啡因
基于生理学的药代动力学模型
精神运动学习
认知
警惕(心理学)
神经生理学
睡眠剥夺对认知功能的影响
心理学
认知心理学
睡眠剥夺
睡眠不足
脑电图
神经科学
药理学
药代动力学
医学
精神科
作者
Tim Halverson,Christopher W. Myers,Jeffery M. Gearhart,Matthew W. Linakis,Glenn Gunzelmann
摘要
Most computational theories of cognition lack a representation of physiology. Understanding the cognitive effects of compounds present in the environment is important for explaining and predicting changes in cognition and behavior given exposure to toxins, pharmaceuticals, or the deprivation of critical compounds like oxygen. This research integrates physiologically based pharmacokinetic (PBPK) model predictions of caffeine concentrations in blood and tissues with ACT-R's fatigue module to predict the effects of caffeine on fatigue. Mapping between the PBPK model parameters and ACT-R model parameters is informed by the neurophysiological literature and established associations between ACT-R modules and brain regions. The results from three such parameter mappings are explored to explain observed data from sleep-deprived participants performing the psychomotor vigilance test with and without caffeine. Predicted caffeine concentrations in the brain are used to modulate procedural parameters in the fatigue module to explain caffeine's effects on multiple performance metrics.
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