三阴性乳腺癌
对映体
三重阴性
绝对构型
癌细胞系
灵芝
癌症
乳腺癌
立体化学
化学
生物
灵芝
癌细胞
传统医学
医学
遗传学
作者
Jiaojiao Zhang,Ping-Xia Guo,Zhong-Hui Yang,David Cai,Wenwen Dai,Qing Lü,Yong‐Xian Cheng
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-06-01
卷期号:167: 105505-105505
标识
DOI:10.1016/j.fitote.2023.105505
摘要
Ganoderpetchoids A-E and (-)-dayaolingzhiol H, six undescribed meroterpenoids, were isolated from Ganoderma petchii. Their structures including the relative configurations were identified by means of spectroscopic methods and 13C NMR calculations. Chiral separation of the new racemics was performed to afford their respective enantiomers. The absolute configurations of the new isolates were clarified by computational approaches, CD comparisons and X-ray diffraction analysis. Biological studies toward triple negative breast cancer indicated that (+)-6 and (-)-6 significantly inhibit the migration of MDA-MB-231 cell line.
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