钳子运动
位阻效应
催化作用
化学
磷化氢
反应性(心理学)
沮丧的刘易斯对
氢化物
组合化学
药物化学
有机化学
金属
路易斯酸
医学
替代医学
病理
作者
Zeyuan Wei,Hengxu Li,Yujie Wang,Qiang Liu
标识
DOI:10.1002/anie.202301042
摘要
The reactivity of metal-hydride complexes can be harnessed by the modification of ancillary ligands. With the aim of improving the hydride-donor ability of the key Mn-H intermediate and reducing steric hindrance, we herein report the rational design of a versatile and efficient NHC-based NNC-pincer Mn catalyst for hydrogenation reactions. This newly developed catalyst exhibited higher activity than the corresponding NNP-pincer Mn catalyst owing to its reduced steric hindrance and enhanced Mn-H σ-bonding orbital energy level through a π-antibonding interaction. Using this highly active NNC-pincer Mn catalyst, a rich array of polar unsaturated compounds (>80 examples) including esters, N-heteroarenes, amides, carbonates, and urea derivatives, were successfully hydrogenated under relatively mild conditions. This work represents a rare example of a general phosphine-free Mn-catalyzed hydrogenation system.
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