医学
四分位数
脂肪肝
混淆
全国健康与营养检查调查
体质指数
优势比
内科学
置信区间
逻辑回归
人口
生理学
胃肠病学
疾病
内分泌学
环境卫生
作者
Bo Zhang,Jun-Chuan Cao,Furong Liu,Zhuo Deng,Chuan-Jing Chen,Yongye Sun
出处
期刊:PubMed
日期:2023-01-01
卷期号:32 (1): 158-167
标识
DOI:10.6133/apjcn.202303_32(1).0019
摘要
The relationship between dietary folate intake and non-alcoholic fatty liver disease (NAFLD) is controversial. This study aimed to investigate the relationship between dietary folate equivalent (DFE) intake and NAFLD in U.S. adults.Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 were used. NAFLD was defined as a US fatty liver index (FLI) value ≥30. DFE intake was assessed by two 24-hour dietary recall interviews. Multivariable logistic regression models and restricted cubic spline models were used to investigate the association between DFE intake and NAFLD risk.A total of 6,603 adult participants were included in this study. After adjusting for multiple confounding factors, the odds ratios and 95% confidence intervals of NAFLD for the highest quartile versus lowest quartile of DFE intake was 0.77(0.59-0.99). In stratified analyses by sex, age, and body mass index (BMI), there were statistically significant negative associations between DFE intake and NAFLD risk in women and participants with BMI ≥25. Dose-response analysis indicated a negative linear correlation between DFE intake and NAFLD risk.Dietary folate equivalent intake is negatively associated with NAFLD risk in the general U.S. adult population.
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