Self-Assembly of Polyoxometalate-Based Nanoparticle Surfactants in Solutions

Nanoparticle surfactants (NPSs) are an emergent class of amphiphiles attractive for their controllable assembly at the liquid–liquid interface. In this work, intriguing self-assembly behavior and stimuli-responsiveness of NPSs in homogeneous solutions are presented. With β-cyclodextrin-grafted polyoxometalates (POMs) and ferrocene (or azobenzene)-terminated polystyrene in water/tetrahydrofuran, POM-based NPSs are formed via host–guest interactions and self-organize to vesicles driven by solvent-phobic effects. The tunable supramolecular interactions allow these assemblies to be responsive to redox or light stimulus, respectively, affording an on-demand assembly/disassembly capacity that shows promise in delivery and release applications.