化学
烷基
基质(水族馆)
串联
联轴节(管道)
阳极
组合化学
药物化学
有机化学
物理化学
电极
材料科学
海洋学
地质学
复合材料
冶金
作者
Weijie Deng,Xinling Li,Zhenjie Li,Yating Wen,Ziliang Wang,Zeyin Lin,Yibiao Li,Jinhui Hu,Yubing Huang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-12-14
卷期号:25 (51): 9237-9242
标识
DOI:10.1021/acs.orglett.3c03984
摘要
With cyanopyridines and alkyl bromides as coupling partners, an electrochemically driven C4-selective decyanoalkylation has been established to access diverse 4-alkylpyridines in one step. The reaction proceeds through the single electron reduction/radical-radical coupling tandem process under mild electrolytic conditions, achieving the cleavage of the C(sp2)-CN bond and the formation of C(sp3)-C(sp2). The practicality of this protocol is illustrated by no sacrificial anodes, a broad substrate scope, and gram-scale synthesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI