人血清白蛋白
荧光
化学
白蛋白
光热治疗
人类血液
体内
人血浆
血清白蛋白
生物化学
色谱法
纳米技术
医学
材料科学
生物
生物技术
物理
量子力学
生理学
作者
Yuting Wang,Fangjun Huo,Caixia Yin
标识
DOI:10.1021/acs.jpcb.3c06915
摘要
Human serum albumin (HSA) acts as a repository and transporter of substances in the blood. An abnormal concentration may indicate the occurrence of liver- and kidney-related diseases, which has attracted people to investigate the precise quantification of HSA in body fluids. Fluorescent probes can combine with HSA covalently or noncovalently to quantify HSA in urine and plasma. Moreover, probes combined with HSA can improve its photophysical properties; probe-HSA has been applied in real-time monitoring and photothermal and photodynamic therapy in vivo. This Review will introduce fluorescent probes for quantitative HSA according to the three reaction mechanisms of spatial structure, enzymatic reaction, and self-assembly and systematically introduce the application of probes combined with HSA in disease imaging and phototherapy. It will help develop multifunctional applications for HSA probes and provide assistance in the early diagnosis and treatment of diseases.
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