苯并呋喃
体内
化学
细胞凋亡
铅化合物
药理学
哌嗪
程序性细胞死亡
细胞生长
细胞培养
细胞周期
体外
细胞周期检查点
立体化学
生物化学
生物
生物技术
遗传学
有机化学
作者
Tanner J. Schumacher,Naresh Sah,Komaraiah Palle,Jon N. Rumbley,Venkatram R. Mereddy
标识
DOI:10.1016/j.bmcl.2023.129425
摘要
This work describes about the synthesis and evaluation of substituted benzofuran piperazines as potential anticancer agents. The synthesized candidates have been evaluated for their cell proliferation inhibition properties in six murine and human cancer cell lines. In vitro evaluation of apoptosis and cell cycle analysis with the lead candidate 1.19 reveals that necrosis might be an important pathway for the candidate compounds to cause cell death. Further, in vivo evaluation of the lead compound shows that this candidate is well tolerated in healthy mice. Additionally, an in vivo anticancer efficacy study in mice using a MDA-MB-231 xenograft model with the lead compound provides good anti-cancer efficacy.
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