BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3
纤毛形成
胰腺
腺泡细胞
胰腺炎
腺泡
内科学
医学
内分泌学
癌症研究
细胞生物学
生物
纤毛
作者
Mario A. Shields,Anastasia E. Metropulos,Christina Spaulding,Khulood Alzahrani,Tomonori Hirose,Shigeo Ohno,Thao D. Pham,Hidayatullah G. Munshi
Combined, this study demonstrates how Par3 restrains chronic pancreatitis-induced changes in the pancreas and identifies a potential role for BET inhibitors to attenuate pancreas injury and facilitate regeneration.
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(2025-6-4)
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