Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis

This study explores the genetic links between obstructive sleep apnoea (OSA) and cardiovascular diseases (CVDs).Key findings are as follows:Strong genetic correlations were found between OSA and five CVDs: coronary artery disease, heart failure (HF), myocardial infarction, stroke, and atrial fibrillation. Novel correlated and causal loci were identified.Atrial fibrillation was identified as a causal factor for OSA, while OSA was a causal factor for HF.Future research is needed to explore these genetic mechanisms further and improve understanding of the connections between OSA and CVDs.