Wnt信号通路
化学
软骨内骨化
体内
骨愈合
转染
软骨
胫骨骨折
细胞生物学
胫骨
信使核糖核酸
体外
分子生物学
信号转导
生物
解剖
生物化学
基因
生物技术
作者
Anna Laura Nelson,Chiara Mancino,Xueqin Gao,Joshua A. Choe,Laura Chubb,Katherine B. Williams,Molly Czachor,Ralph Marcucio,Francesca Taraballi,John P. Cooke,Johnny Huard,Chelsea S. Bahney,Nicole Ehrhart
标识
DOI:10.1016/j.bioactmat.2024.05.020
摘要
, revealing significantly more bone volume over total volume in the 45 μg group. Thus, we generated a novel mRNA-based therapeutic encoding a β-catenin mRNA and optimized an SM-102-based LNP to maximize transfection efficacy with a localized delivery.
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