Central nervous system involvement in systemic lupus erythematosus: Data from the Spanish Society of Rheumatology Lupus Register (RELESSER)

Highlights-Major CNS NP-SLE contributes to a 2-times higher mortality in SLE.-The individual major CNS NP-SLE manifestations contribute differently to survival in SLE.-CVD, organic brain syndrome and seizure are associated with the highest mortality rates.