Nanomaterials as novel matrices to improve biomedical applications of MALDI-TOF/MS

With the rapid development of biomedical technology, there is an increasing demand for accurate analysis of biomolecules and their interactions. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a novel soft ionization biomass spectrometry technology that can accurately assess the molecular weight of samples quickly and sensitively, and it plays an important role in the analysis and detection of large molecule substances, drug research, and life sciences. In recent years, due to the outstanding performance of nanomaterials, they have been widely used as matrices in drug metabolism research and cancer detection. This paper aims to review the latest research progress of nanomaterials as new matrices for MALDI-TOF MS in enhancing biomedical analysis, discus its value and limitations, and look forward to its future research direction.