Hyaluronic acid-based hydrogels modulate neuroinflammation and extracellular matrix remodelling in multiple sclerosis: insights from a primary cortical cell model

HAS2 mediated hyaluronic acid (HA) synthesis is overexpressed in the cortex after a neuroinflammatory insult creating an extracellular matrix (ECM) scar. This is ameliorated after the treatment with an HA hydrogel through its antiinflammatory effect and ECM remodelling ability.