The fidelity control of nucleotide selectivity in SARS-CoV-2 RdRp through amino acid mutations via molecular dynamics simulations

The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 (CoV2-RdRp) is a promising antiviral drug target serving for nucleotide analogue drug such as a remdesivir nucleotide analogue (RTP). In this study, based...