Targeting epithelial-mesenchymal transition: breviscapine, a promising natural product in cancer and organ fibrosis treatment

In recent years, more and more studies have shown that breviscapine and its main active component scutellarin can play an inhibitory role in EMT of different types of tumors and organs, thus interfering with the malignant process of tumor and organ fibrosis. Based on Web of Science, PubMed and CNKI databases, this paper comprehensively reviewed the in vitro and in vivo research results of breviscapine targeting EMT against tumor and organ fibrosis, including the regulation of EMT-related signaling pathways, in order to provide reference for further research and clinical application of breviscapine in the treatment of related diseases.