Peripheral Blood ILC2s Levels Are Associated with Autoimmunity and Atopy in Chronic Spontaneous Urticaria: A Preliminary Study

Reduced peripheral ILC2s levels in CSU may indicate autoimmune dysregulation. While comparaed with non-atopic CSU, the elevated ILC2s in atopic CSU suggest distinct type 2 inflammatory pathways. Yet, ILC2s don't correlate with clinical severity or treatment response, implying their likely immunomodulatory role in CSU pathogenesis related to autoimmune and atopic mechanisms, not as disease biomarkers. Further research is needed to clarify their exact function and therapeutic potential.