Regiodivergent Access to α- and β-Amino Acids via Solvent-Controlled Rh-Catalyzed Carboamidation of β,γ-Unsaturated Carboxylic Acids

-Ac sitagliptin and rapid access to diverse peptidomimetics, showcasing its potential in streamlining the development of pharmaceuticals and bioactive probes. DFT calculations reveal distinct energy barriers for the rate-determining steps of the two pathways in HFIP and THF, rationalizing the solvent-controlled selectivity.