Mesenchymal Stem Cells and Curcumin Effectively Mitigate Freund’s Adjuvant-induced Arthritis via their Anti-inflammatory and Gene Expressionof COX-1, IL-6 and IL-4

Based on these findings, additive therapeutic effects on RA occur from the combined treatment of curcumin and BM-MSCs compared with their individual use (P < 0.05). Thus, it can be said that both curcumin and BM-MSCs are effective at reducing inflammation while also having beneficial effects on the ankle joint, thymus and spleen.