干细胞
癌症免疫疗法
淋巴因子激活杀伤细胞
肿瘤微环境
生物
细胞疗法
细胞毒性T细胞
癌症
移植
免疫学
过继性细胞移植
造血干细胞移植
NK-92
作者
Hassan Dianat-Moghadam,Mohsen Rokni,Faroogh Marofi,Yunes Panahi,Mehdi Yousefi
摘要
Abstract
Natural killer (NK) cells are key players of the innate immune system. NK cells provide
protection against infectious pathogens and malignancies in cell. This characteristic
may be attributable to their intrinsic diverse potentialities and also their cooperation
with adaptive immune lymphocytes, known as B and T cells. The growth, recurrence,
and metastasis of cancer cells, and the failure of cytoreductive therapies against cancer
cells are due to the small population of intratumor stem‐like cells, called cancer stem
cells (CSCs). Furthermore, NK cells can efficiently eradicate heterogeneous tumor cells
after a long‐term treatment. Therefore, NK cell–based therapy is a promising strategy
to target and break CSC‐associated resistance to anticancer drugs treatment. In this
review, we have presented an overview of the emerging knowledge of the
characteristics, diversities, and mechanism‐driven immune surveillance of human NK
cells and advances in NK cell–based immunotherapies. Finally, we will discuss how
these cells can be applied to introduce the next generation of vaccine‐ and immune‐
based approaches to prevent drug resistance.
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