Here, there, and everywhere: The importance of ER membrane contact sites

It's all about your contacts Membrane contact sites have recently come to the fore of our understanding of interorganelle communication. Wu et al. review how these important structures help to promote a variety of key functions, including organelle division and lipid transfer. Focusing on contacts between the endoplasmic reticulum and a variety of organelles or the plasma membrane reveals the generality and importance of these contacts in cellular homeostasis and organismal health. Science , this issue p. eaan5835