The potential for bilateral high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to modulate motoric-cognitive risk syndrome in older adults

Cognitive and mobility impairment are common in seniors and result in significant disability. Emerging evidence suggests that executive function is involved in gait regulation. HF-rTMS is a relatively safe non-invasive brain stimulation technique that has been shown to enhance motor learning and working memory. However, the role of HF-rTMS has not been adequately explored in modulating the motoric-cognitive risk syndrome, which increases the risk for Alzheimer disease.