Lactobacillus paracasei 乳酸菌抑制胃幽門螺旋桿菌感染之探討

中文摘要 I 英文摘要 III 目錄 V 表目次 VII 圖目次 VIII 第一章 前言及文獻回顧 1 第一節 胃幽門螺旋桿菌 1 第二節 乳酸桿菌 6 第二章 研究動機與目的 11 第三章 材料與方法 13 第一節 實驗材料 13 第二節 實驗架構 18 第三節 實驗設計與方法 19 第四節 統計分析 33 第四章 結果與討論 34 第五章 結論 46 實驗結果圖表 47 參考文獻 62 附件一 人體試驗招募受試者之流程圖 69 附件二 與胃幽門桿菌有關之疾病 70 附件三 台北醫學大學人體試驗同意證明書 71 附件四 台北醫學大學人體試驗志願書 72 附件五 受試者篩選問卷 76 附件六 受試者注意事項 77 附件七 檢測腸道菌相的細菌種類、培養基與培養時間 79 1. Marshall, B. J., and J. R. Warren. 1984. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311-1315. 2. Goodwin, C. S., and B. W. Worsley. 1993. Microbiology of Helicobacter pylori. Gastroenterol Clin North Am 22:5-19. 3. Marshall, B. 2003. Helicobacter pylori: past, present and future. Keio J Med 52:80-85. 4. Lin, J. T., J. T. Wang, T. H. Wang, M. S. Wu, T. K. Lee, and C. J. Chen. 1993. Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. A seroprevalence study in Taiwan. Scand J Gastroenterol 28:1067-1072. 5. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum 61:1-241. 6. Atherton, J. C., R. M. Peek, Jr., K. T. Tham, T. L. Cover, and M. J. Blaser. 1997. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112:92-99. 7. Yahiro, K., T. Niidome, M. Kimura, T. Hatakeyama, H. Aoyagi, H. Kurazono, K. Imagawa, A. Wada, J. Moss, and T. Hirayama. 1999. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem 274:36693-36699. 8. Yahiro, K., A. Wada, M. Nakayama, T. Kimura, K. Ogushi, T. Niidome, H. Aoyagi, K. Yoshino, K. Yonezawa, J. Moss, and T. Hirayama. 2003. Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. J Biol Chem 278:19183-19189. 9. Isomoto, H., J. Moss, and T. Hirayama. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. Tohoku J Exp Med 220:3-14. 10. Cover, T. L., and S. R. Blanke. 2005. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol 3:320-332.