生物
肌动蛋白
细胞生物学
肌动蛋白重塑
细胞骨架
肌动蛋白细胞骨架
病毒
成核
病毒学
细胞
遗传学
有机化学
化学
作者
Timothy P. Newsome,N. Bishara Marzook
标识
DOI:10.1016/j.semcdb.2015.10.008
摘要
Actin nucleation drives a diversity of critical cellular processes and the motility of a select group of viral pathogens. Vaccinia virus and baculovirus, Autographa californica multiple nucleopolyhedrovirus, recruit and activate the cellular actin nucleator, the Arp2/3 complex, at the surface of virus particles thereby instigating highly localized actin nucleation. The extension of these filaments provides a mechanical force that bestows the ability to navigate the intracellular environment and promote their infectious cycles. This review outlines the viral and cellular proteins that initiate and regulate the signalling networks leading to viral modification of the actin cytoskeleton and summarizes recent insights into the role of actin-based virus transport.
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