化学
激进的
试剂
基础(拓扑)
芳基
自由基取代
弱碱
组合化学
药物化学
金属
光化学
有机化学
烷基
数学
数学分析
作者
Denis Koziakov,Michal Májek,Axel Jacobi von Wangelin
摘要
Aromatic thioethers and analogous heavier chalcogenides were prepared by reaction of arene-diazonium salts with disulfides in the presence of the cheap and weak base NaOAc. The mild and practical reaction conditions (equimolar reagents, DMSO, r.t., 8 h) tolerate various functional groups (e.g. Br, Cl, NO2, CO2R, OH, SCF3, furans). Mechanistic studies indicate the operation of a radical aromatic substitution mechanism via aryl, acetyloxyl, thiyl, and dimsyl radicals.
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