莫里斯水上航行任务
超氧化物歧化酶
过氧化氢酶
谷胱甘肽过氧化物酶
化学
平菇
生物化学
淀粉样前体蛋白
阿尔茨海默病
抗氧化剂
心理学
内科学
食品科学
神经科学
医学
认知
疾病
蘑菇
作者
Yan Zhang,Xiaomei Yang,Gang Jin,Xiudong Yang
标识
DOI:10.1016/j.ijbiomac.2016.08.008
摘要
This study was conducted to evaluate the effects of polysaccharides extracted from Pleurotus ostreatus (POP) on d-galactose and AlCl3-induced cognitive impairments. A behavioral test suggested that POP significantly decreased escape latency and increased crossing parameters of platform quadrant in a Morris water maze test. Furthermore, POP decreased error numbers and increased passive avoidance latency in a step-down test. Biochemical examinations revealed that POP significantly elevated superoxide dismutase, glutathione peroxidase, and catalase activities; and reduced malondialdehyde levels and acetylcholinesterase activity. Moreover, POP could decrease amyloid β peptide formation and tau phosphorylation by elevating the expression of protein phosphatase 2A as well as by reducing the expression of amyloid precursor protein (APP), β-site APP clearing enzyme1, and glycogen synthase kinase 3beta. These findings provide scientific evidence to support the exploitation of POP as a safe and effective drug to prevent and treat Alzheimer’s disease.
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