医学
PCSK9
胆固醇
内科学
信使核糖核酸
核糖核酸
内分泌学
脂蛋白
低密度脂蛋白胆固醇
低密度脂蛋白受体
生物化学
基因
生物
作者
Kausik K. Ray,Ulf Landmesser,Lawrence A. Leiter,David Kallend,Robert Dufour,Mahir Karakas,Tim N. Hall,Roland P.T. Troquay,Traci Turner,Frank L.J. Visseren,Peter Wijngaard,R. Scott Wright,John J.P. Kastelein
标识
DOI:10.1056/nejmoa1615758
摘要
In a previous study, a single injection of inclisiran, a chemically synthesized small interfering RNA designed to target PCSK9 messenger RNA, was found to produce sustained reductions in low-density lipoprotein (LDL) cholesterol levels over the course of 84 days in healthy volunteers.
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