Voltage-gated chloride channels and neoplasms

Voltage-gated chloride channels play an important role in the cell membrane potential,cell volume regulation,organelle acidification,and cell proliferation and apoptosis in different cell types.They are composed of 2 identical pores which form a homodimeric membrane protein and appear a typical double-barrel structure.In recent years,it has been reported that voltage-gated chloride channels are closely related to the proliferation,invasion,apoptosis,and multidrug resistance of tumor cells.Therefore,voltage-gated channels might be a potential anticancer target.