Objective To evaluate the clinical value of testing D-dimer and fibrinogen in patients with pulmonary embolism. Methods D-dimer and fibrinogen of 42 patients with pulmonary embolism were determined. The data of the D-dimer and fibrinogen were analyzed and compared with the compared group. Results Comparing with the compared group, Level of D-dimer and fibrinogen in pulmonary embolism group showed great differences(P0.05). The sensitivity rates of D-dimer and fibrinogen in pulmonary embolism were 85.8%,70.2% respectively, the sepcific rates were 42.5%,34.2% respectively, while sensitivity and specificity of combined testing were respectively 95.4%and56.8%. Conclusion Combined testing of plasma D-dimer and fibrinogen has great clinical significance in the final diagnosis of pulmonary embolism.