Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics

Helicobacter pylori infection may cause many gastric disease, such as peptic ulcers, chronic atrophic gastritis, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer.The different clinical outcomes of Helicobacter pylori infection are related to H. pylori virulence factors and host gene polymorphism.H.pylori had been confirmed to be the class I carcinogen by the World Health Organization and International Agency for Research on Cancer Consensus Group (IARC) in1994.Most severe diseases always occur in the background that certain microbial virulence markers (e.g.cagA, vacA) and susceptible host genetic polymorphisms harboured together.Herein, we reviewed the association with H. pylori-related gastric diseases in relation to diffirent H. pylori types and the host polymorphisms.