Study on Effectiveness and Safety of Optimum Program for Prevention and Treatment of Renal Insufficiency of Diabetic Nephropathy

Objective To optimize the program for prevention and treatment of renal insufficiency of diabetic nephropathy (DN) and to evaluate the effectiveness and safety of the program of TCM treatment based on syndrome differentiation for protection of renal function.Methods With method of randomized,blind,controlled and multi—central clinical study,221 cases of renal insufficiency of DN were divided into group A (TCM treatment based on syndrome differentiation group),group B (Losartan group) and group C (TCM treatment plus Losartan treatment group).The treatment course was 3 months.Results After treatment,the increasing amplitude of serum creatimine clearance rate (Ccr) in group A was higher than in group B(P0.05),and the decreasing amplitude of serum creatimine(SCr) in group A was higher than in group B(P0.01) and C(P0.05);There was no significant difference in blood urea nitrogen (BUN) and 24—hour urinary protein among the 3 groups(P0.05).After treatment of 3 months,serum alanine aminotransferase (ALT),electrocardiogram(ECG) and B—ultrasonic examination results of the liver,gallbladder,spleen and pancreas did not have significant change(P0.05) with on significant difference among the 3 groups(P0.05).Conclusion The TCM treatment program in addition to diet regulation,decreasing blood sugar and expectant treatment iseffective and safe in improvingrenal function,and the program is better than Losartan in increasing Ccr and decreasing SCr.