Objective To investigate the outcome of the wavefront-guided laser in situ keratomileusis(LASIK) in correcting low and midrange myopia.Methods The wavefront-guided laser in situ keratomileusis(W-LASIK) were performed on 48 eyes.The visual acuity,refraction and higher order aberration were determined pre-and post-operation,and the outcomes were compared with those of 42 eyes following standard-LASIK(S-LASIK).Results At 1 month after wavefrontguided surgery,compared with the BCVA of pre-operation,the UCVA was raised 2 lines in 3 eyes,1 line in 16 eyes,was not changed in 24 eyes,and was decreased 1 line in 3 eyes.The outcomes were superior to those of the S-LASIK group.The coma following W-LASIK was lower than that following S-LASIK.In addition,the post-operative root mean square(RMSh) negatively related to the pre-operative vertical coma.Conclusions The wavefront-guided laser in situ keratomileusis can decrease the higher order aberration of myopia patients and increases the quality of vision.