Clinical effect of radiofrequency hyperthermia combined with chemotherapy on stage IV gastric cancer

OBJECTIVE:To observe the short-term clinical effect and adverse reactions of combination of radiofrequency hyperthermia with FOLFOX6 project chemotherapy and abdominal cavity chemotherapy for Ⅳ stage gastric cancer.METHODS:A total of 96 Ⅳ stage gastric cancer were randomized into case group and control group.All the cases of the two groups were administrated FOLFOX6 project chemotherapy.The cases with abdominal membrane metastasis and abdominal dropsy were given abdominal cavity chemotherapy.There were 50 cases in the case group,and 46 cases in the control.The cases of the case group were given 60 minutes radiofrequency hyperthermia in abdominal region on d1,d3,d5 in the cycle.But those of the control were not given hyperthermia.After 14ds another cycle repeated.One months later after 4 cycles,short-term clinical effect,cancer pain effect and adverse reactions were evaluated.RESULTS:The short-term clinical effect of case group was 72.0%.That of the control was 39.1%.The case group was higher than the control group(P0.05).There were 42 cases abdominal region cancer pain in the case group.There were 40 cases cancer pain in the control.The cancer pain effect of the former was 95.2%,higher than that of the control 62.5%(P0.05).There was no difference of adverse reactions between the two groups(P0.05).CONCLUSION:Abdominal region radiofrequency hyperthermia can raise short-term clinical effect of vein chemotherapy and abdominal cavity chemotherapy in Ⅳ stage gastric cancer,raise cancer pain effect,but not raise adverse reactions of chemotherapy.