This paper discusses the computation of wind response of high-rises based on the vibration theory of cantilever beam and the principle of measuring their wind load in a wind tunnel using a high frequency balance.It further analyzes the height distributions of the mean wind force, fluctuating wind force, wind induced vibrating inertial force, and the determination of the equivalent static wind load required by the structural design of the buildings.This method can be used as a reference for determining the wind load of high-rises in their structural design.The result points out that the method of equivalent static wind load calculation in this paper is suitable for the along-wind wind force but exists theoretical error to across-wind wind force due to the influence of vortex shedding.