Light-Triggered Switching of Reversible and Alterable Biofunctionality via β-Cyclodextrin/Azobenzene-Based Host–Guest Interaction

Most of the recent reports focused on using cyclodextrin/azobenzene/polymer for reversible immobilization of biomolecules, the reversible photoswitching of biofunctions via universal and low-cost strategy, were barely investigated. Herein, we report light-triggered switching of reversible and alterable biofunctionality on silicon interface via β-cyclodextrin/azobenzene based host-guest interaction. Biofunctional azobenzene-grafted polymers were synthesized and assembled onto β-cyclodextrin anchored interfaces to form "smart" monolayers of light-triggered switchable brushes. The photoresponsive interfaces exhibit reversible and alterable biofunctionality switching from antibacterial/hemostatic to bioadhesion/anticoagulant upon ultraviolet and visible (UV-vis) light cycles.