Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points

Abstract A novel approach to determine vitamin B We used a database with all four markers (n=5211) plus folate measurements (n=972). A biomarker The predictive functions We provide equations that combine two, three or four biomarkers into one diagnostic indicator, thereby rescaling unmatched data into the same coordinate system. Adjustment of this indicator is required if serum folate is <10 nmol/L and tHcy is measured. Revised cut-points and guidelines for using this approach are provided.